Search results for "Inonotus obliquus"
showing 3 items of 3 documents
Biological and anticancer properties of Inonotus obliquus extracts
2018
Abstract Inonotus obliquus (IO) has traditionally been used in folk medicine in the treatment of gastrointestinal cancer, cardiovascular disease and diabetes. The aim of our study was to evaluate the biological and metabolic properties of IO extracts. Free radical scavenging properties, inhibition of the activity of xanthine oxidase (XOi), induction of reactive oxygen species (ROS) production, cell viability and expression of superoxide dismutase (SOD1), catalase (CAT) and KI67 mRNA in the human colorectal adenocarcinoma (Caco-2) and normal human skin fibroblast (BJ) cell lines were measured. It was found that 80% ethanol extract of IO exhibited the highest properties inhibiting the activit…
Lanostanoids from fungi: a group of potential anticancer compounds.
2012
Lanostanes are a group of tetracyclic triterpenoids derived from lanosterol. They have relevant biological and pharmacological properties, such as their cytotoxic effects via induction of apoptosis. This review compiles the most relevant lanostanoids studied from 2000 to 2011, principally those isolated from Ganoderma lucidum and other related fungi, such as Poria cocos, Laetiporus sulphureus, Inonotus obliquus, Antrodia camphorata, Daedalea dickinsii, and Elfvingia applanata, which have great potential as anticancer agents because of their cytotoxic or apoptotic effects. The compounds were selected on the basis of their proapoptotic mechanisms, through their ability to modify transcription…
Čagas (Inonotus obliquus) lipofīlo ekstraktvielu profila analītiskais raksturojums un autentiskuma novērtējums
2021
Maģistra darbā tika apkopota zinātniskā literatūra par čagu, tās lipīdu sastāvu, farmakoloģisko iedarbību, lipīdu analīzes metodēm un ķīmijmetrikas metodi. Tika izolēti čagas lipofilie savienojumi ar dažādām ekstrakcijas metodēm, izmantojot dažādus nepolārus šķīdinātājus, lai iegūtu maksimālu ekstrakcijas iznākumu. Iegūtie lipofilie ekstrakti tika atvasināti ar BSTFA un analizēti, izmantojot gāzu hromatogrāfiju-masspektrometriju. Tika autentificēti čagas paraugi, izmantojot izotopu attiecības masas spektrometriju (IRMS), daudzelementu analīzi un salīdzināti dažādas izcelsmes lipofilo ekstraktvielu sastāvi. Tika frakcionēts čagas lipīdu ekstrakts un pārbaudīta iegūto frakciju ietekme uz pato…